Evidence map›Paper›PMID 40720540›Full record

ArticleThe journal of physical chemistry letters2025

Long-Range Allosteric Modulation of DNA Duplex Dynamics Induced by Pyrrole-Imidazole Polyamide Binding.

Sophie E T Kendall-Price, Ryan J O Nichol, Andrea Taladriz-Sender, Ryan Phelps, Partha Malakar, Gregory M Greetham, Glenn A Burley, Neil T Hunt

Abstract read
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In one paragraph

Article in The journal of physical chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie E T Kendall-PriceDepartment of Chemistry and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, U.K.
Ryan J O NicholDepartment of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1BX, U.K.
Andrea Taladriz-SenderDepartment of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1BX, U.K.ORCID 0000-0002-8274-4761
Ryan PhelpsSTFC Central Laser Facility, Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, U.K.ORCID 0000-0001-9036-2133
Partha MalakarSTFC Central Laser Facility, Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, U.K.ORCID 0000-0001-6874-7010
Gregory M GreethamSTFC Central Laser Facility, Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0QX, U.K.ORCID 0000-0002-1852-3403
Glenn A BurleyDepartment of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1BX, U.K.ORCID 0000-0002-4896-113X
Neil T HuntDepartment of Chemistry and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, U.K.ORCID 0000-0001-7400-5152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The allosteric modulation of the structural dynamics of double-stranded DNA (dsDNA) duplexes as a function of distance from the site of a minor groove binding ligand is reported. Time-resolved temperature-jump infrared spectroscopy is used to interrogate the impact of binding a pyrrole-imidazole polyamide to dsDNA sequences 8-14 base-pairs in length. Our results demonstrate that the binding of the hairpin polyamide to its target site (5'-WWGTACW-3'; W = A/T) causes a marked suppression of structural dynamics, such as end fraying, with suppression observed in both the 3' and 5' directions. Quantitative analysis of end fraying suppression reveals a propagation length for dynamic modulation of 30 base-pairs. Identifying the structural impact of minor groove binding to dsDNA sequences furthers our understanding of the influence of dsDNA recognition and informs the design of next-generation synthetic transcription factors.

Indexed as

DNAImidazolesNylonsPyrrolesAllosteric RegulationBinding SitesNucleic Acid ConformationDNAimidazoleImidazolesNylonsPyrroles

Identifiers

PMID40720540
PMCPMC12337142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.