ArticleNeuropsychology2025
Affliction class moderates the dementing impact of amyloidopathy.
Article in Neuropsychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biomarker affliction classes contribute additively to observed dementia severity and prospective conversion risk.Journal of Alzheimer's disease : JAD · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveThe treatment of dementia is increasingly likely to focus on dementia-related biomarkers. Unfortunately, there is variability with regard to biomarker-related effects. This analysis tests an algorithm capable of identifying persons adversely impacted by any dementia-related biomarker in this case, amyloidopathy as estimated by positron emission tomography (PET).
method
results39.3% of subjects with (+) PET results were assigned to the afflicted class. The afflicted subjects had greater dementia severity and higher amyloid burdens. These effects persisted at 36 months. Furthermore, the association between amyloid burden and dementia severity was moderated by affliction class. Afflicted nondemented cases with positive PET findings were more likely to convert to clinical "Alzheimer's disease" over 48 months, by Cox's
conclusionOur approach could allow for more accurate prediction of biomarker effects and guide precision interventions against specific biomarkers. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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Registered trials
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