Evidence map›Paper›PMID 40720308›Full record

Trial reportAmerican journal of physical medicine & rehabilitation2025

Forced-Rate Aerobic Cycling Improves Locomotor Function and Gait Biomechanics in Individuals With Chronic Stroke: A Randomized Controlled Trial.

Susan M Linder, Ryan Rilinger, Ken Learman, Mandy Miller Koop, Matt Streicher, Sara Davidson, Courtney Miller, Donayja Harris, Patrick Corrigan, Francois Bethoux and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physical medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryan RilingerCleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
Ken LearmanYoungstown State University, Youngstown, Ohio.
Mandy Miller KoopCleveland Clinic, Department of Biomedical Engineering, Cleveland, Ohio.
Matt StreicherCleveland Clinic, Department of Biomedical Engineering, Cleveland, Ohio.
Sara DavidsonCleveland Clinic, Concussion Center, Cleveland, Ohio.
Courtney MillerFrom the Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, Ohio.
Donayja HarrisFrom the Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, Ohio.
Patrick CorriganFrom the Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, Ohio.
Francois BethouxFrom the Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, Ohio.
Jay L Alberts

Funding

Cost-effectiveness and efficacy of a combined intervention to facilitate motor recovery following strokeK01HD092556 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI LINDER, SUSAN MARIE · 2018 to 2022
$666k
NICHD NIH HHS K01 HD092556
6 · The paper itself

Abstract

objectiveWhile cycling and walking are different motor tasks, both require the rapid reciprocal activation and relaxation of lower extremity muscles in a synergistic manner, promoting coordination patterns similar to walking. The aim of this secondary analysis was to examine the effects of forced-rate cycling on gait biomechanics after stroke.

designA randomized controlled trial was conducted investigating the neuroplastic effects of forced-rate cycling on upper extremity motor recovery in individuals ( n = 60) after stroke. In this secondary analysis, a subset of participants ( N = 45) completed biomechanical gait assessment at baseline and postintervention.

resultsGait velocity increased in the cycling group by 0.08 m/sec and in the control group by 0.02 m/sec, though a group difference was not observed ( P = 0.195). Walking capacity (6-min walk test) significantly improved by 53.3 m for the cycling group versus 15.6 m for the control group ( P = 0.0036). Improvements in spatiotemporal characteristics in the cycling group included increased step length, cadence, and time spent in single-limb support, in addition to paretic limb kinetics.

conclusionsImprovements in gait velocity after forced-rate cycling were accompanied by normalization of gait biomechanics rather than exaggerated compensatory strategies, supporting the use of aerobic cycling as a viable and safe intervention to improve locomotor control after stroke.

Indexed as

BicyclingExercise TherapyGaitGait Disorders, NeurologicStroke RehabilitationAgedBiomechanical PhenomenaChronic DiseaseFemaleHumansMaleMiddle AgedRecovery of FunctionStrokeGait DisordersHemiparesisLocomotor TrainingRecovery of FunctionWalking

Identifiers

PMID40720308
PMCPMC12969801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.