Trial reportPsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2025
Do lab-based assessments of pretreatment smoking reinforcement and cue-specific craving predict smoking cessation with varenicline?
Trial report in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03262662 (EVarQuit), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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EVarQuit: Extended Pre-quit Varenicline to Assist in Quitting Smoking
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11 authors.
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Abstract
objectiveIndividual differences in smoking reinforcement and cue-specific cigarette craving are theorized to influence smoking cessation and relapse. However, there has been little laboratory research that prospectively evaluates these relationships. The present study evaluated whether lab-based indices of pretreatment smoking reinforcement and cue-specific craving predicted subsequent bio-verified abstinence.
methodParticipants were 253 adults (aged 28-70, 54% female, 78% White, 3% Hispanic) who reported smoking more than five cigarettes per day when enrolled in a randomized, double-blind, placebo-controlled smoking cessation trial (NCT03262662). During a lab visit ∼1 week before treatment began, participants completed the Choice Behavior under Cued Conditions task. On each of the 36 Choice Behavior under Cued Conditions trials, participants spent between $0.01 and $0.25 for a chance (5%-95%) to sample a cigarette or a cup of water. All participants received varenicline, either during Weeks 1-15 or 4-15 of the study, along with counseling at each visit, and attempted to quit smoking at the end of Week 4. Cotinine-bio-verified (< 15 ng/mL) 7-day point-prevalence abstinence was assessed at Weeks 6, 8, 15, and 28. The predictive validity of pretreatment smoking reinforcement and cue-specific craving on abstinence were examined in logistic regressions.
resultsAs predicted, greater pretreatment smoking reinforcement predicted lower odds of abstinence, an effect that did not vary significantly across time, treatment groups, or biological sex. Pretreatment cue-specific craving was not predictive of abstinence.
conclusionsThis study highlights the theoretical importance of smoking reinforcement and the predictive utility of Choice Behavior under Cued Conditions in identifying those at risk for relapse. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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