Evidence map›Paper›PMID 40720211›Full record

ReviewRNA biology2025

Derailing the host machinery to achieve replication: how viroid and viroid-like RNAs successfully copy their genomes in hostile territory.

Kriton Kalantidis, Martha Tselika, Paraskevi Kallemi, Eirini Bardani, Nikoleta Kryovrysanaki, Konstantina Katsarou

Abstract readReview
In one paragraph

Review in RNA biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kriton KalantidisDepartment of Biology, University of Crete, Voutes University Campus, Heraklion, Greece.ORCID 0000-0002-6698-8563
Martha TselikaDepartment of Biology, University of Crete, Voutes University Campus, Heraklion, Greece.
Paraskevi KallemiDepartment of Biology, University of Crete, Voutes University Campus, Heraklion, Greece.
Eirini BardaniDepartment of Biology, University of Crete, Voutes University Campus, Heraklion, Greece.
Nikoleta KryovrysanakiInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece.
Konstantina KatsarouDepartment of Biology, University of Crete, Voutes University Campus, Heraklion, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular infectious RNAs have been known for several decades. Their biology has been intriguing from the beginning, partly due to the antithesis between their efficiency and tiny size. Amongst infectious circular RNAs viroids hold a special place not only because they were the first to be characterized as such but also because they have been extensively studied as a group. Viroids do not encode proteins and therefore have to rely for their biological cycle on the host factors. As a result, the identification and functional characterization of host factors enabling their biological cycle has been of prime importance to the community. With the advent of high throughput sequencing technologies, viroid-like infectious RNAs have been found in plants, fungi, and animals, including mammals, making understanding their biology even more interesting and important. In this review, we summarize what is known about the replication of these tiny yet very efficient infectious RNAs.

Indexed as

Genome, ViralHost-Pathogen InteractionsRNA, ViralViroidsVirus ReplicationAnimalsPlantsRNA, CircularRNA, CircularRNA, ViralcircularRNAcrRNAHDVparasitic RNArolling circle replication

Identifiers

PMID40720211
PMCPMC12382478

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.