ArticleJournal of neurophysiology2025
Oscillatory dynamics in isolated dystonia: five hundred hours of chronic invasive multisite motor network recordings.
Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Acute and Chronic Local Field Potential Recordings in Dystonia-A Systematic Review.Movement disorders clinical practice · 2026Review
- Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia.EBioMedicine · 2026Article
- Target-specific modulation of cortical narrowband gamma by basal ganglia nuclei: a case report.Frontiers in human neuroscience · 2026Article
- Translational prospectives for deep brain stimulation and low-intensity focused ultrasound neuromodulation: IFCN Handbook chapter.Clinical neurophysiology practice · 2026Review
- Dithering suppresses half-harmonic neural synchronisation to photic stimulation in humans.Brain stimulationArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Dystonia is a movement disorder characterized by involuntary muscle contractions, often treated with bilateral pallidal deep brain stimulation (DBS). However, optimizing DBS therapy remains challenging due to delayed clinical effects and a lack of objective biomarkers in dystonia. Using an investigational sensing-enabled DBS device attached to both cortical and pallidal leads, we recorded over 500 h of neural activity in a patient with cervical dystonia before and during chronic stimulation therapy while the individual went about their normal daily life. During off-stimulation settings, we observed increased low-frequency power (3-12 Hz) and a distinct narrowband gamma oscillation (∼60 Hz) in the sensorimotor cortex, both of which correlated with the severity of dystonic head tremor. DBS suppressed both pathological low-frequency activity and narrowband gamma oscillations while inducing stimulation-entrained gamma oscillations at half the stimulation frequency (65 Hz). Reductions in low-frequency power and increases in entrained gamma power were associated with improvements in dystonia severity, as measured by blinded clinical assessments of home video and video-derived kinematics, including head tremor amplitude and head angle deviations. The amplitude of gamma entrainment depended on stimulation parameters, including amplitude, frequency, and electrode contact. These findings suggest that gamma oscillations and their entrainment by stimulation may serve as an objective marker of DBS effectiveness in dystonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.