Evidence map›Paper›PMID 40720160›Full record

ArticleAnalytical chemistry2025

Simple One-Step Deuterated Peracetylation-MALDI-MS/MS (OSDPM) Strategy for Structural Sequencing of Glycosaminoglycan Oligosaccharides.

Zhonghua Li, Yuxiao Zhang, Fan Bai, Yi Lasanajak, Qing Zhang, Maomao Yan, Lauren Byrd-Leotis, David A Steinhauer, Haojie Lu, Xuezheng Song

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhonghua LiDepartment of Biochemistry and Molecular Biology, NHC Key Laboratory of Glycoconjugate Research Ministry of Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0002-7625-7043
Yuxiao ZhangInstitutes of Biomedical Sciences and Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Fan BaiDepartment of Biochemistry, Emory Glycomics and Molecular Interactions Core, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Yi LasanajakDepartment of Biochemistry, Emory Glycomics and Molecular Interactions Core, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Qing ZhangDepartment of Biochemistry, Emory Glycomics and Molecular Interactions Core, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-0203-4437
Maomao YanDepartment of Biochemistry, Emory Glycomics and Molecular Interactions Core, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Lauren Byrd-LeotisDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
David A SteinhauerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Haojie LuDepartment of Biochemistry and Molecular Biology, NHC Key Laboratory of Glycoconjugate Research Ministry of Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0003-3477-7662
Xuezheng SongDepartment of Biochemistry, Emory Glycomics and Molecular Interactions Core, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0003-1751-2785

Funding

Natural Glycans for Functional GlycomicsR44GM133252 · NIGMS · NATGLYCAN, LLC · PI SMITH, DAVID FLETCHER · 2020 to 2021
$1.9M
Next Generation Glycan Microarray using DNA-coded glycans and Next Generation Sequencing (NGS)R01GM137011 · NIGMS · EMORY UNIVERSITY · PI SONG, XUEZHENG · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM137011NIGMS NIH HHS R44 GM133252
6 · The paper itself

Abstract

Heparin and heparan sulfate (HP/HS), characterized by heterogeneous sulfation motifs, uronic acid epimerization (GlcA/IdoA), and variations in N-acetyl and N-sulfo groups, play pivotal roles in regulating physiological and pathological processes. This inherent structural complexity, resulting from sulfation heterogeneity and epimeric diversity, poses significant challenges for the HP/HS structural analysis. Current labor-intensive multistep derivatization methods coupled with LC-MS/MS or MS

Indexed as

DeuteriumGlycosaminoglycansOligosaccharidesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAcetylationAnimalsHeparan SulfateSwineTandem Mass SpectrometryDeuteriumGlycosaminoglycansHeparan SulfateOligosaccharides

Identifiers

PMID40720160
PMCPMC13016202

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.