Evidence map›Paper›PMID 40720071›Full record

ArticleIndian pediatrics2025

Diagnostic Performance of Mean Neutrophil Volume in Neonatal Sepsis.

Santosh Kumar Panda, T Jenith, Nageswar Sahu, Palash Das, Sourav Padhee

Abstract read
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In one paragraph

Article in Indian pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Santosh Kumar PandaDepartment of Neonatology, Kalinga Institute of Medical Sciences KIIT DU, Bhubaneswar, Odisha, India.
T JenithDepartment of Pediatrics, Kalinga Institute of Medical Sciences, KIIT DU, Bhubaneswar, Odisha, India.
Nageswar SahuDepartment of Pathology, Kalinga Institute of Medical Sciences KIIT DU, Bhubaneswar, Odisha, India.
Palash DasDepartment of Pediatrics, Kalinga Institute of Medical Sciences, KIIT DU, Bhubaneswar, Odisha, India. palash.das@kims.ac.in.ORCID 0000-0002-4205-1194
Sourav PadheeDepartment of Research and Development, Kalinga Institute of Medical Sciences, KIIT DU, Bhubaneswar, Odisha, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the diagnostic performance of mean neutrophil volume (MNV) in culture-positive neonatal sepsis. MNV (index test), measured using an automated hematology analyzer, was compared to blood culture (reference test) in a study including 535 neonates; 86 were culture-positive sepsis, 192 were probable sepsis, and 257 were not septic. The median (Q1, Q3) MNV (fL) was higher in culture-positive septic neonates compared to non-septic neonates [154 (152, 157) vs. 136 (133, 143), P = 0.001]. MNV > 151 fL diagnosed sepsis with 84.8% sensitivity, 89.4% specificity, 76% positive predictive value, and 94.7% negative predictive value with area under the receiver operating characteristic curve (AUROC) of 0.950 (95% CI 0.921, 0.971) suggesting it as a useful diagnostic tool for culture-positive neonatal sepsis.

Indexed as

Neonatal SepsisNeutrophilsFemaleHumansInfant, NewbornLeukocyte CountMaleSensitivity and SpecificityAutomated analyzerMNVNewbornSensitivitySepticemiaSpecificity

Identifiers

PMID40720071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.