Evidence map›Paper›PMID 40720007›Full record

ArticleScience China. Life sciences2025

Multi-omics analysis revealed the addiction to glutamine and susceptibility to de novo lipogenesis of endometrial neoplasm.

Yuemeng Zhu, Yingxin Zheng, Qing Zhang, Leshi Chen, Yitong Ouyang, Zhiqiang Song, Bing Zhao, Chao Gu, Beihua Kong, He Huang and 1 more

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuemeng Zhu *Obstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China.
Yingxin Zheng *Obstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China.
Qing Zhang *Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, 250012, China.
Leshi Chen *Obstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China.
Yitong OuyangObstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China.
Zhiqiang SongObstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China.
Bing ZhaoObstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China.
Chao GuObstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China. drchaogu@126.com.
Beihua KongDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, 250012, China. kongbeihua@sdu.edu.cn.
He HuangObstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China. he_huang@fudan.edu.cn.
Jin LiObstetrics and Gynecology Hospital, State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University, School of Life Sciences, Zhongshan Hospital and Institute of Metabolism and Integrative biology, Fudan University, Shanghai, 200438, China. li_jin_lifescience@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endometrium is a proliferative tissue controlled by the menstrual cycle. Endometrial hyperplasia (EH) is a type of neoplastic disease that may develop into endometrial hyperplasia with atypia (EHA) or endometrial adenocarcinoma (EA). We performed a multi-omics analysis of a collection of endometrial tissues with four different proliferative statuses from two independent cohorts of patients. A positive association between the level of glutamine and malignancy, as well as addiction of EHA/EA neoplasms to glutamine, was identified. Further investigation revealed the dual mechanism by which glutamine influences the development of endometrial neoplasms. On one hand, glutamine regulates the level of c-MYC by controlling its translational process. On the other hand, glutamine is a major source of energy for endometrial neoplasms. Reprogramming the glutamine metabolism towards de novo lipogenesis affects the growth of endometrial adenocarcinoma in vitro, ex vivo and in vivo. Our study revealed the importance of maintaining metabolic homeostasis in endometrial tissues. The enhancement of de novo lipogenesis is a promising therapeutic strategy for treating endometrial adenocarcinoma.

Indexed as

Endometrial NeoplasmsGlutamineLipogenesisAdenocarcinomaAnimalsCell Line, TumorCell ProliferationEndometrial HyperplasiaEndometriumFemaleGene Expression Regulation, NeoplasticHumansMiceMultiomicsProto-Oncogene Proteins c-mycGlutamineProto-Oncogene Proteins c-mycendometrial cancerglutaminelipogenesis

Identifiers

PMID40720007

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.