Evidence map›Paper›PMID 40719978›Full record

ArticleIndian journal of pediatrics2025

Insulin Like Growth Factor-1 as a Screening Tool to Differentiate Between Idiopathic Short Stature and Growth Hormone Deficiency.

Vaman Khadilkar, Madhura Karguppikar, Aboli Bhalerao, Karishma Bhade, Anuradha V Khadilkar

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Article in Indian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Vaman KhadilkarGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, 411 001, India.
Madhura KarguppikarGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, 411 001, India.
Aboli BhaleraoGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, 411 001, India.
Karishma BhadeGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, 411 001, India.
Anuradha V KhadilkarGrowth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, 411 001, India. anuradhavkhadilkar@gmail.com.ORCID 0000-0002-4660-3013

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measurement of serum insulin-like growth factor-1 (IGF-1) is a useful screening test for growth hormone deficiency (GHD) because unlike growth hormone, it has minimal circadian variation. In this retrospective study, the authors compared IGF-1 concentrations in children with GHD vs. idiopathic short stature (ISS) to define IGF-1 cut-off to differentiate the two. Of the 75 children studied, 38 were GHD and 37 ISS. Weight, height, BMI Z-scores, bone age: age ratio, IGF-1 concentrations and IGF-1 Z-scores were significantly lower in the GHD group. The best IGF-1 Z-score cut-off was -2.41 (sensitivity: 74.3% and specificity: 89.2%). Many children who are non-GH deficient fail growth hormone stimulation tests and get wrongly diagnosed as GHD and receive a lesser dose of GH leading to suboptimal response. In such patients, if the IGF-1 is well above the cut-off (-2.41), other diagnostic possibilities including ISS may be considered for GH dose adjustment.

Indexed as

Growth DisordersHuman Growth HormoneInsulin-Like Growth Factor IAdolescentBody HeightChildChild, PreschoolDiagnosis, DifferentialDwarfismFemaleHumansInsulin-Like PeptidesMaleRetrospective StudiesSensitivity and SpecificityHuman Growth HormoneInsulin-Like Growth Factor IInsulin-Like PeptidesGrowth hormone deficiencyIdiopathic short statureIndian childrenInsulin-like growth factor-1

Identifiers

PMID40719978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.