Trial reportSports medicine (Auckland, N.Z.)2025
Erythrocyte Glycolytic and Redox Metabolism Affects Muscle Oxygenation and Exercise Performance: A Randomized Double-Blind Crossover Study in Men.
Trial report in Sports medicine (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity and oxidative stress biomarkers in humans: a systematic review and quantitative meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Cryoprotective strategies for frozen erythrocytes in POCT whole blood reference materials progress and challenges.Analytical and bioanalytical chemistry · 2026Review
- Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells.Blood red cells & iron · 2026Article
- Proteoforms as the true units of physiological function.European journal of applied physiology · 2026Review
- Erythrocytes as a Source of Exerkines.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundErythrocytes are traditionally considered passive oxygen carriers, yet their energetic and redox metabolism plays a critical role in regulating oxygen kinetics.
objectiveThis study integrates experimental and computational data to provide a comprehensive analysis of erythrocyte metabolism in response to exercise-induced oxidative stress.
methodsThe study consisted of three phases: in vivo, ex vivo, and computational. A total of 20 male participants underwent a randomized crossover experiment with two conditions: oxidative stress (eccentric contractions) and control. Oxidative stress was induced via leg eccentric contractions, and its effects on erythrocyte glycolytic and redox metabolism, arm muscle oxygenation, and arm exercise performance were evaluated. The study protocol was preregistered on the Open Science Framework ( https://osf.io/ub6zs ).
resultsEccentric contractions altered oxidative stress markers in erythrocytes (+ 22% F
conclusionIn a comprehensive exercise study investigating mechanistic relationships in erythrocyte biology, we show that erythrocyte metabolism (1) responds dynamically to exercise, (2) becomes dysregulated under oxidative stress, and (3) may partly influence muscle oxygenation and performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.