Evidence map›Paper›PMID 40719857›Full record

ArticleEuropean journal of nutrition2025

Plant-based diets, genetic predisposition, and the risk of adult-onset asthma A prospective study.

Juanjuan Zhang, Bin Wang, Zhiyuan Tang, Yuerong He, Yuchuan He, Ruiqi An, Liangkai Chen, Hehua Zhang, Yang Xia

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Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Juanjuan Zhang *School of Public Health, Hebei University, Baoding, China.
Bin Wang *Department of Endocrinology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhiyuan TangAcademic Affairs Office, Hebei University, Baoding, China.
Yuerong HeSchool of Public Health, Hebei University, Baoding, China.
Yuchuan HeSchool of Public Health, Hebei University, Baoding, China.
Ruiqi AnSchool of Public Health, Hebei University, Baoding, China.
Liangkai ChenDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hehua ZhangClinical Research Center, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, Liaoning, China. sj_zhanghh@126.com.
Yang XiaDepartment of Data Center, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, Liaoning, China. xytmu507@126.com.ORCID http://orcid.org/0000-0001-8783-1592

Funding

Liaoning Revitalization Talents Program XLYC2203168
6 · The paper itself

Abstract

backgroundEmerging evidence has linked diets rich in plant-based foods with a lower risk of asthma, while the prospective evidence is limited. Therefore, we aimed to explore the association of plant-based diet quality with the risk of adult-onset asthma, and whether this association was modified by genetic predisposition.

methodsA total of 163,689 asthma-free participants were enrolled in from the UK Biobank. Plant-based diet indices (including overall plant-based diet index [PDI], healthful plant-based diet index [hPDI], and unhealthful plant-based diet index [uPDI]) were calculated based on 17 major food groups from Oxford WebQ. Genetic predisposition for asthma was characterized using a weighted polygenic risk score (PRS). Cox proportional hazards models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs).

resultsDuring a median follow-up of 12.0 years, a total of 3015 new adult-onset asthma cases were documented. Compared to the lowest tertile, the multivariable-adjusted HRs (95% CIs) of adult-onset asthma in the highest tertile were 0.90 (0.83-0.99; P for trend = 0.029), 0.90 (0.82-0.99; P for trend = 0.025), and 1.23 (1.12-1.34; P for trend < 0.001), for the PDI, hPDI, and uPDI, respectively. In the analysis of joint associations of PDIs and PRS with the risk of adult-onset asthma, neither overall PDI nor hPDI showed a significant association in the high asthma-PRS group compared to the reference group, while uPDI did not show a significant association in the low asthma-PRS group.

conclusionsFor adult-onset asthma, both the overall PDI and hPDI were associated with a reduced risk of development, whereas uPDI was associated with an increased risk. Although no genetic effects were found to interact with the associations mentioned above, the associations showed slight variations across different genetic risk groups. Future studies are needed to explore these associations in more depth.

Indexed as

AsthmaDiet, VegetarianGenetic Predisposition to DiseaseAdultAgedDiet, Plant-BasedFemaleFollow-Up StudiesHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsUnited KingdomAsthmaGenetic riskPlant-based diet indicesProspective study

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PMID40719857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.