ArticleImmunologic research2025
SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation.
Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular plasticity of LAMA3 across the disease spectrum: pathogenic mechanisms and clinical translation.Histochemistry and cell biology · 2026Pooled it
- Rethinking PDAC: from immunological silence to therapeutic opportunity.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Basement membranes (BMs) and tumor-associated macrophages (TAMs) are crucial stromal components in pancreatic cancer (PC), critically influencing disease progression. Bulk and single-cell RNA-seq (scRNA-seq) data were acquired from publicly available databases. Through integration of multiple machine learning algorithms, we developed and validated a BM-related subtype and prognostic signature in PC cohorts. The expression profiles of BM-related genes in PC were verified using experimental approaches. We further investigated the functional mechanisms of a core gene in PC progression. Additionally, we characterized the TAM landscape in PC, revealing distinct TAM subsets associated with tumor progression and their dynamic interactions with BM components. Based on BM-related gene expression profiles, PC samples were stratified into two distinct subtypes. Our integrated prognostic signature combining LASSO and survival-SVM algorithms demonstrated robust performance in predicting PC outcomes and clinical characteristics. LAMA3, ITGA3, and ITGB6 showed higher expression in PC specimens versus normal controls. Functional experiments confirmed that ITGB6 knockdown markedly suppressed PC progression. Through integrative analysis of multiple scRNA-seq datasets of PC, we established a single-cell landscape of TAMs and ductal cells, respectively. SPP1 + TAMs correlated with poor PC prognosis and facilitated tumor progression through ITGB6-mediated interactions. In this study, we established novel PC subtypes and constructed a prognostic signature based on BM-related genes. An atlas of TAMs was constructed in PC. SPP1 + macrophages drove pancreatic cancer progression via ITGB6-mediated interactions.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.