Evidence map›Paper›PMID 40719839›Full record

ArticlePhysical and engineering sciences in medicine2025

Modelling single cell dosimetry and DNA damage of targeted alpha therapy using Monte-Carlo techniques.

Adam L Jolly, Andrew L Fielding

Abstract read
In one paragraph

Article in Physical and engineering sciences in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Monte Carlo microdosimetry ofEJNMMI physics · 2026
    Article
  2. Monte Carlo simulations ofMedical physics · 2026
    Article
  3. Ultrasmall AuExploration (Beijing, China) · 2026
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Adam L JollySchool of Chemistry and Physics, Queensland University of Technology (QUT), Brisbane, Australia.
Andrew L FieldingSchool of Chemistry and Physics, Queensland University of Technology (QUT), Brisbane, Australia. a.fielding@qut.edu.au.ORCID http://orcid.org/0000-0001-9955-4609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted alpha therapy (TαT) employs alpha particle-emitting radioisotopes conjugated to tumour-specific carriers to precisely irradiate tumour cells. Monte-carlo techniques have been used to accurately simulate absorbed dose and DNA damage for the four promising TαT radionuclides, Actinium-225 (

Indexed as

Alpha ParticlesDNA DamageModels, BiologicalMonte Carlo MethodRadiometryActiniumAstatineCell NucleusHumansRadioisotopesActiniumActinium-225AstatineRadioisotopesMonte-Carlo simulationNuclear medicineRadiotherapyTargeted alpha therapy

Identifiers

PMID40719839
PMCPMC12738655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.