ArticleAging clinical and experimental research2025
Association between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesDynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa).
methodsWe analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of < 26 kg for men and < 16 kg for women. Abdominal obesity was defined as waist circumference of > 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer's Association criteria were used to define MCI. Multivariable logistic regression was performed.
resultsData on 32,715 individuals aged ≥ 50 years were analyzed [mean (SD) age 62.1 (15.6) years; 48.3% males]. Among those aged 50-64 years, dynapenia alone and DAO were significantly associated with MCI with the OR for DAO (OR = 1.79; 95%CI = 1.26-2.56) being higher than that of dynapenia alone (OR = 1.40; 95%CI = 1.15-1.71). In those aged ≥ 65 years, only dynapenia alone (OR = 1.53; 95%CI = 1.23-1.89) was significantly associated with MCI but not DAO. Abdominal obesity alone was not significantly associated with MCI in both age groups.
conclusionsAmong community-dwellers in six LMICs, DAO was significantly associated with MCI among middle-aged individuals, but not among older people. However, it is important to note that the study was cross-sectional in nature, and thus, it is not known whether DAO leads to MCI or vice versa. Therefore, future longitudinal studies are necessary to clarify temporal associations and possible causality.
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