Evidence map›Paper›PMID 40719639›Full record

Observational studyESC heart failure2025

Intense optimization of oral therapy rapidly restores respiratory function in worsening heart failure patients.

Hajer Yaakoubi, Lotfi Boukadida, Marwa Toumia, Anaïs Caillard, Houda Ben Soltane, Rahma Jaballah, Imen Trabelsi, Randa Dhaoui, Asma Zorgati, Hamdi Boubaker and 7 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hajer YaakoubiEmergency Department of Sahloul, University of Sousse, Sousse, Tunisia.
Lotfi BoukadidaEmergency Department of Sahloul, University of Sousse, Sousse, Tunisia.
Marwa ToumiaEmergency Department of Fattouma Bourguiba, University of Monastir, Monastir, Tunisia.
Anaïs CaillardDepartment of Anesthesia-Reanimation, Cavale Blanche Hospital, Univ Brest, Laboratoire ORPHY, Brest, France.ORCID https://orcid.org/0000-0001-7162-9971
Houda Ben SoltaneEmergency Department of Farhat Hached, University of Sousse, Sousse, Tunisia.
Rahma JaballahEmergency Department of Sahloul, University of Sousse, Sousse, Tunisia.
Imen TrabelsiEmergency Department of Sahloul, University of Sousse, Sousse, Tunisia.
Randa DhaouiEmergency Department of Fattouma Bourguiba, University of Monastir, Monastir, Tunisia.
Asma ZorgatiEmergency Department of Sahloul, University of Sousse, Sousse, Tunisia.
Hamdi BoubakerEmergency Department of Fattouma Bourguiba, University of Monastir, Monastir, Tunisia.
Meriem KhroufEmergency Department of Farhat Hached, University of Sousse, Sousse, Tunisia.
Zied MezgarEmergency Department of Farhat Hached, University of Sousse, Sousse, Tunisia.
Houda Ben SalahEmergency Department of Sahloul, University of Sousse, Sousse, Tunisia.
Alexandre MebazaaUniversité Paris Cité, Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis Lariboisière, AP-HP, Paris, France.
Benjamin DeniauPARCC U970, Université Paris Cité, Paris Transplant Group, Paris, France.
Semir NouiraEmergency Department of Fattouma Bourguiba, University of Monastir, Monastir, Tunisia.
Riadh BoukefEmergency Department of Sahloul, University of Sousse, Sousse, Tunisia.

Funding

S-Form Pharma
6 · The paper itself

Abstract

aimsBreathlessness is the primary symptom of decompensated heart failure (HF), but the prevalence and evolution of persistent respiratory distress post-hospitalization remain unclear. METHODS AND

resultsThe Longitudinal Observational Study for mIddle Term Follow-up Patients Admitted for Acute Dyspnea in TunIsia (SIDI) study is a prospective and multicentre study on HF patients with preserved ejection fraction admitted for acute dyspnoea. Patients were followed for 6 months. The primary endpoint was to assess the incidence of persistent respiratory distress and factors linked to respiratory recovery at Day 90. The secondary endpoint was rehospitalization and/or death at Day 90 and 180. Among 231 patients, 140 had SpO

conclusionsPersistent respiratory distress is frequent in the months following HF hospitalization. Optimized guideline-directed therapy and close follow-up improve respiratory recovery. SpO

Indexed as

DyspneaHeart FailureRecovery of FunctionStroke VolumeAdministration, OralAgedDisease ProgressionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesTime FactorsDyspnoeaGDMTHeart failureHospital dischargeIntensive follow‐upPersistent respiratory distress

Identifiers

PMID40719639
PMCPMC12450774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.