Evidence map›Paper›PMID 40719546›Full record

Observational studyTranslational vision science & technology2025

Regional and Layer Specific Retinal Capillary Red Blood Cell Velocimetry in Healthy Human Subjects.

Sarah Aman, Yuxin Xia, Milad Lashgari Faghani, Bailee Alonzo, Melat Asebot, Anna Tang, Xuejuan Jiang, Viet-Hoan Le, Ruikang K Wang, Amir H Kashani

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah AmanDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuxin XiaDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Milad Lashgari FaghaniDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Bailee AlonzoDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Melat AsebotDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anna TangDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xuejuan JiangDepartment of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
Viet-Hoan LeDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Amir H KashaniDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Assessment of Retinal Capillary Density, Morphology and Function in Retinal Vascular Disease Using Novel OCT Angiography Based MetricsR01EY030564 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H · 2019 to 2024
$3.5M
Ultra-wide field optical coherence tomography based angiography for imaging diabetic retinopathyR01EY028753 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2018 to 2021
$2.2M
NEI NIH HHS R01 EY028753NEI NIH HHS R01 EY030564
6 · The paper itself

Abstract

Purpose: To investigate retinal capillary and choriocapillaris red blood cell (RBC) velocity using optical coherence tomography angiography (OCTA)-based velocimetry in healthy human subjects. Methods: This was a cross-sectional, observational study using a 1050-nm swept-source OCTA instrument with a new M-B scan protocol to obtain 2 × 2-mm2 volumes in the central, nasal, and temporal macula regions. An eigendecomposition-based analysis estimated the average mean frequency (MF) of moving particles in the radial peripapillary capillaries (RPCs), superficial retinal layer (SRL), deep retinal layer (DRL), and choriocapillaris (CC) in each region. MF is linearly proportional to RBC velocity. A linear mixed model evaluated the effect of retinal layer and region on MF. Results: Sixty-five subjects (median age, 46 years; interquartile range, 27-67; 97 eyes, 54% females) were included in the study. MF values for SRL, DRL, and CC among all regions were 166 ± 44, 106 ± 36, and 313 ± 33Hz, respectively (P < 0.05). The lowest MF was in the RPCs (133 ± 41; P < 0.001). There were significant differences in MFs between age groups, as well as all layers within and across different regions (P < 0.05). In the central macula, there was a correlation between MF and age in the SRL, DRL, and CC (r = -0.581, -0.439, and -0.658, respectively; P < 0.001). Weaker associations were noted in the peripapillary and temporal retina. Conclusions: Retinal and choriocapillaris RBC velocity varies with age, layer, and retinal region. These variations may provide insight into vascular aging and blood flow regulation. Translational Relevance: Age-related and regional changes in capillary and choriocapillaris RBC velocity are important for understanding retinal vascular health and disease.

Indexed as

CapillariesErythrocytesRetinal VesselsAdultAgedBlood Flow VelocityChoroidCross-Sectional StudiesFemaleHealthy VolunteersHumansMaleMiddle AgedRheologyTomography, Optical Coherence

Identifiers

PMID40719546
PMCPMC12312764

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.