Trial reportMicrobiology spectrum2025
Impact of fluoride varnish and oral health education on caries increment and dental plaque microbiota among children with early mixed dentition: a three-armed 24-month randomized controlled trial.
Trial report in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Human Oral-AssociatedMicroorganisms · 2026Review
- Dynamic changes in oral microbiome composition during early childhood caries management.Applied microbiology and biotechnology · 2026Article
- Evolving Patterns of Oral Disease Burden in China, 1990-2021: Evidence From the Global Burden of Disease Study.International dental journal · 2026Article
- Minimally Invasive Interventions for Childhood Caries: A Scoping Review of Their Applicability in Public Health and Community Settings.Healthcare (Basel, Switzerland) · 2026Review
- Behavioral change and oral health literacy among elementary students after a school-based oral health education program.Journal of education and health promotion · 2026Article
- Caries Activity and Its Associated Factors Among Primary Caregivers of Preschool Children.International journal of dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Dental caries is the most prevalent oral disease globally. A 24-month randomized controlled trial was conducted among 236 children aged between 7 and 8 years (ChiCTR2400084030). They were randomly allocated into three groups and received the following biannual interventions: Group 1: topical fluoride varnish (TFV) using 5% sodium fluoride; Group 2: oral health education (OHE); and Group 3: TFV + OHE. The interventions lasted for 12 months, and a final examination was conducted after 24 months to assess whether the desired effects sustained after the cessation of interventions. After 12-month interventions, when demographic and socioeconomic factors were adjusted, children in Group 1 were more likely to have new caries on their permanent first molars when compared to Group 2 (odds ratio [OR] = 2.86, 95% confidence interval [CI] 1.33, 6.14) or Group 3 (OR = 2.28, 95% CI 1.09, 4.78). There was no significant difference in Shannon diversity index across the three groups. Among the top 10 most abundant genera,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.