Evidence map›Paper›PMID 40719430›Full record

ReviewMinerva surgery2025

Current insights into breast and ovarian cancer risk: a contemporary review.

Natalie A Gaughan, Nicole Rademacher, Christine Rogers, Anna Purdy, Joanne D Mattingly, Caitlin R Patten, Adrienne N Cobb, Amanda L Kong, Chandler S Cortina

Abstract readReview
In one paragraph

Review in Minerva surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Identification and Computational Analysis ofMedical sciences (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalie A GaughanDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Nicole RademacherDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Christine RogersMedical College of Wisconsin Cancer Center, Milwaukee, WI, USA.
Anna PurdyDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Joanne D MattinglyDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Caitlin R PattenDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Adrienne N CobbDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Amanda L KongDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Chandler S CortinaDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA - ccortina@mcw.edu.

Funding

Understanding the Influence of Hormone Therapy on Breast Cancer Risk and Screening through Mixed MethodsK08CA276706 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Chandler Scott Cortina · 2023 to 2026
$841k
NCI NIH HHS K08 CA276706
6 · The paper itself

Abstract

Breast and ovarian cancer account for millions of new cancer diagnoses worldwide annually. An individual's risk of breast and/or ovarian cancer is the result of a complex interplay between non-modifiable and modifiable factors. This review provides a comprehensive map of the current state of our understanding of breast and ovarian cancer risk as conducted through a literature review utilizing PubMed and Cochrane review as primary databases and the selection process prioritized year of publication for up-to-date research and journal impact factor as criteria of research credibility. We review non-modifiable risk factors, such as genetic variations, age, sex assigned at birth, and reproductive history as well as how advances in genetic mapping have led to increased insight in pathogenic germline variants. Additionally, we discuss modifiable factors such as lifestyle and environmental exposures which allow the opportunity for intervention to reduce risk. Contemporary high risk screening tools, including understanding their strengths and weaknesses, are discussed and how they can lend to the determination of eligibility for preventive measures, including risk-reducing operations. The unique challenges of under-represented groups, such as non-Hispanic Black women, transgender/nonbinary/and gender-diverse individuals, and Asian and Pacific Islander populations are reviewed in the context of breast and ovarian cancer risk. Future research on improving risk assessment tools and identifying genomic variants will yield improved personalized healthcare solutions.

Indexed as

Breast NeoplasmsOvarian NeoplasmsFemaleGenetic Predisposition to DiseaseHumansRisk AssessmentRisk Factors

Identifiers

PMID40719430
PMCPMC12355728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.