Evidence map›Paper›PMID 40719425›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Sex and Age but Not Body Mass Index (BMI) Predict Serum Retinol Binding Protein 4 (RBP4) and Transthyretin (TTR) Concentrations.

Aprajita S Yadav, Lindsay C Czuba, Jerry Zhu, Jeffrey LaFrance, Aurora K Authement, Lindsey Williams, Judy Y Chen, Estell Williams, Zoe Parr, Saurabh Khandelwal and 3 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. RBP4 in Ageing.Biomedicines · 2026
    Review
  4. Sex and Age but Not Body Mass Index (BMI) Predict Serum Retinol Binding Protein 4 (RBP4) and Transthyretin (TTR) Concentrations.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aprajita S YadavDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-4181-7522
Lindsay C CzubaDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-9142-5706
Jerry ZhuDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.
Jeffrey LaFranceDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.
Aurora K AuthementDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0003-3677-5214
Lindsey WilliamsDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.
Judy Y ChenDivision of General Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
Estell WilliamsDivision of General Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
Zoe ParrDivision of General Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
Saurabh KhandelwalDivision of General Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
Daniel KimDivision of General Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.
Katya B RubinowDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-6505-5657
Nina IsoherranenDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-9548-3126

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Mechanisms of Regulation of Retinoic Acid HomeostasisR01GM111772 · NIGMS · UNIVERSITY OF WASHINGTON · PI ISOHERRANEN, NINA · 2014 to 2021
$3.0M
Mechanisms of Regulation of Retinoic Acid HomeostasisR01DK143511 · NIDDK · UNIVERSITY OF WASHINGTON · PI Nina Isoherranen · 2025 to 2026
$1.2M
HHS|National Institutes of Health (NIH) R01GM11172HHS|National Institutes of Health (NIH) T32DK007247HHS|National Institutes of Health (NIH) T32GM007750HHS|National Institutes of Health (NIH) TL1TR002318NCATS NIH HHS TL1 TR002318NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK143511NIDDK NIH HHS T32 DK007247NIGMS NIH HHS R01 GM111772NIGMS NIH HHS T32 GM007750University of Washington
6 · The paper itself

Abstract

Increased serum concentrations of retinol (vitamin A) and its binding protein retinol binding protein 4 (RBP4) have been linked to progressive obesity, type 2 diabetes, and reduced liver or kidney function. It has been suggested that body mass index (BMI) and serum RBP4 concentrations correlate. Whether this correlation is due to obesity or associated disorders such as insulin resistance or steatotic liver disease is not known. In circulation, RBP4 forms a complex with transthyretin (TTR). Whether the formation of the RBP4-TTR complex is altered with progressive obesity remains to be determined. The goal of this study was to establish whether serum RBP4, retinol, and TTR concentrations change with BMI in a population without diabetes or organ impairment. Fasting serum concentrations of RBP4, TTR, and retinol were measured by LC-MS/MS in individuals with a broad range of BMI (21-56 kg/m

Indexed as

Body Mass IndexPrealbuminRetinol-Binding Proteins, PlasmaAdultAgedAge FactorsFemaleHumansMaleMiddle AgedObesitySex FactorsVitamin AYoung AdultPrealbuminRBP4 protein, humanRetinol-Binding Proteins, PlasmaTTR protein, humanVitamin Aobesityretinolretinol binding protein 4 (RBP4)transthyretin (TTR)vitamin A

Identifiers

PMID40719425
PMCPMC12302666

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.