ReviewAnnals of medicine2025
Autonomic dysfunction in multiple system atrophy: from pathophysiology to clinical manifestations.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Neural Correlates of Apathy in Multiple System Atrophy: A Clinical and Perfusion Imaging Study.European journal of neurology · 2026Article
- Small-Conductance CaNeuroscience bulletin · 2026Review
- Targeting the neuro-immune axis: immunological mechanisms and therapeutic strategies in male sexual dysfunction.Journal of neuroinflammation · 2026Review
- Extensive dysautonomia in early-stage multiple system atrophy reflects survival differences: insights from data-driven subtypes.Journal of neurology · 2026Article
- Levodopa intolerance as a potential clinical red flag for neuronal intranuclear inclusion disease (NIID) in atypical parkinsonism: a case report.BMC neurology · 2026Article
- Sexual dysfunction in movement disorders: prevalence, clinical features, associated factors and management.Clinical parkinsonism & related disorders · 2026Review
- Factors associated with orthostatic hypotension presence and severity in multiple system atrophy: a cross-sectional study.Frontiers in neurology · 2026Article
- A case report of syndrome of inappropriate antidiuretic hormone secretion unveiling hypothalamic involvement in multiple system atrophy.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMultiple system atrophy (MSA) is a sporadic, fatal, and rapidly progressive neurodegenerative disease of unknown etiology, pathologically characterized by the presence of α-synuclein (α-syn) immunoreactive cytoplasmic inclusions in oligodendrocytes. The deposition of α-synuclein in highly interconnected neuronal networks with different neurochemistry properties in different regions of the cortex, diencephalon, brain stem and spinal cord leads to early onset and extensive autonomic dysfunction in MSA. Mainly affected areas include the hypothalamus, pons, raphe nucleus, locus coeruleus, arcuate nucleus, dorsal vagus nucleus, fuzzy nucleus, the thoracolumbar middle lateral column and Onuf's nucleus of the spinal cord. Clinical manifestations include orthostatic hypotension, incomplete bladder emptying, erectile dysfunction, and constipation. DISCUSSION: In this review, we aim to discuss and summarize the clinicopathological correlation of MSA autonomic dysfunction, and focus on the pathophysiological mechanisms of various autonomic dysfunction, from neural control networks under normal physiological conditions to specific pathological involvement structures in MSA. In addition, we also elaborated on the corresponding clinical manifestations caused by various pathological structures.
conclusionsIn summary, the autonomic dysfunction of MSA involves the comprehensive control of cardiovascular, urinary, reproductive, and gastrointestinal functions by the autonomic nervous network in the central nervous system (CNS). The currently summarized physiology and pathophysiology of MSA have not been fully clarified. Further and deeper studies are needed to elucidate the relationship between pathogenesis and clinical manifestations of MSA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.