Evidence map›Paper›PMID 40719318›Full record

ArticleAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2025

Effectiveness of the iVac System Compared to Conventional Irrigation and Ultrasonic Activation in Reducing Microbial Biofilm, Lipopolysaccharides and Apical Extrusion.

Brenda P F A Gomes, Ana B S Lopes, Emelly Aveiro, Lidiane M Louzada, Ederaldo P Godoi-Junior, Pedro I G Fagundes, Esdras G Alves-Silva, Antônio A L Moura-Filho, Rodrigo Arruda-Vasconcelos, Juliana D Bronzato

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brenda P F A GomesDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-8449-0646
Ana B S LopesDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
Emelly AveiroDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
Lidiane M LouzadaDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
Ederaldo P Godoi-JuniorDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
Pedro I G FagundesDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
Esdras G Alves-SilvaDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
Antônio A L Moura-FilhoDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
Rodrigo Arruda-VasconcelosDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-0968-0212
Juliana D BronzatoDivision of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-8249-7916

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 164905/2020-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 303852/2019-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 421801/2021-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 15/23479-5Fundação de Amparo à Pesquisa do Estado de São Paulo 17/25090-3Fundação de Amparo à Pesquisa do Estado de São Paulo 17/25242-8Fundação de Amparo à Pesquisa do Estado de São Paulo 19/19300-0Fundação de Amparo à Pesquisa do Estado de São Paulo 21/13871-6Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 2036/17
6 · The paper itself

Abstract

This in vitro study evaluated the effectiveness of irrigation techniques (IT)-conventional irrigation (CI), ultrasonic activation (UA), and iVac system (IA)- using 2.5% NaOCl and saline in reducing Enterococcus faecalis, Escherichia coli and Candida albicans in root canals and intratubular dentine. It also assessed the reduction of lipopolysaccharides (LPS) and apical extrusion. Lower premolar roots were contaminated and divided based on IT and irrigants, with saline as control. Microbiological and LPS samples were collected before and after IT. The apical extrusion volume was determined. Results showed that when NaOCl was used, there was no statistical difference between the ITs regarding CFU reduction and between UA and IA regarding LPS reduction. When saline was used, IA was the most effective technique in reducing CFU and LPS. Regarding apical extrusion, IA caused the lowest irrigant extrusion. In conclusion, IA reduced the levels of LPS, microorganisms and apical extrusion.

Indexed as

BiofilmsLipopolysaccharidesRoot Canal IrrigantsRoot Canal PreparationTherapeutic IrrigationTooth ApexCandida albicansDental Pulp CavityEnterococcus faecalisEscherichia coliHumansIn Vitro TechniquesSodium HypochloriteLipopolysaccharidesRoot Canal IrrigantsSodium Hypochloriteapical negative pressureendodonticsmicrobiologyroot canal irrigantsultrasonics

Identifiers

PMID40719318
PMCPMC12712880

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.