Evidence map›Paper›PMID 40719194›Full record

ArticleMacromolecular rapid communications2025

Engineering pH-Responsive Nanocarriers via an Optimized Synthesis of PMOXA-b-PDPA Amphiphilic Diblock Copolymers.

John Peter Coats, Anamarija Nikoletić, Lukas Heuberger, Voichita Mihali, Cora-Ann Schoenenberger, Ionel Adrian Dinu, Cornelia G Palivan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John Peter CoatsDepartment of Chemistry, University of Basel, Basel, Switzerland.
Anamarija NikoletićDepartment of Chemistry, University of Basel, Basel, Switzerland.
Lukas HeubergerDepartment of Chemistry, University of Basel, Basel, Switzerland.
Voichita MihaliDepartment of Chemistry, University of Basel, Basel, Switzerland.
Cora-Ann SchoenenbergerDepartment of Chemistry, University of Basel, Basel, Switzerland.
Ionel Adrian DinuDepartment of Chemistry, University of Basel, Basel, Switzerland.
Cornelia G PalivanDepartment of Chemistry, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0001-7777-5355

Funding

Swiss Nanoscience InstituteUniversity of Basel
6 · The paper itself

Abstract

pH-responsive nanocarriers have gain significant attention due to their ability to provide controlled cargo delivery with high precision in response to specific stimuli. However, the polymers used in the self-assembly of these nanocarriers must be carefully designed to meet the requirements of bio-relevant delivery. Here, we present an optimized synthesis of poly(2-methyl-2-oxazoline)-block-poly(2-(diisopropylamino)ethyl methacrylate) (PMOXA-b-PDPA) block copolymers tailored for obtaining carriers with vesicle architecture and thin membranes for an improved release behavior. By systematically modifying the synthesis conditions, we obtain a small library of copolymers, focusing on low molecular weight (MW) variants to reduce the membrane thickness of the resulting vesicles. We investigate the impact of membrane thickness on the kinetics and efficiency of cargo release in response to a pH shift from neutral to slightly acidic conditions that are particularly relevant in pathological environments like tumors. Model cargos of varying MWs, including doxorubicin hydrochloride, exhibited differential release profiles under these pH conditions. Together with no cytotoxicity, the thin membrane represents key aspects that support further development of such carriers for therapeutic applications.

Indexed as

Drug CarriersMethacrylatesNanoparticlesOxazolesPolymersPolymethacrylic AcidsDoxorubicinDrug LiberationHumansHydrogen-Ion ConcentrationMolecular StructurePolyaminesDoxorubicinDrug CarriersMethacrylatesOxazolespoly(2-(diisopropylamino)ethyl methacrylate)poly(2-methyl-2-oxazoline)PolyaminesPolymersPolymethacrylic Acidscargo encapsulationpolymer synthesisself‐assemblytriggered release

Identifiers

PMID40719194
PMCPMC12536392

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.