Evidence map›Paper›PMID 40719087›Full record

ReviewKlinische Monatsblatter fur Augenheilkunde2025

Understanding Glaucoma: Why it Remains a Leading Cause of Blindness Worldwide.

Tienan Qi, Hanhan Liu, Layla Frühn, Katrin Löw, Claus Cursiefen, Verena Prokosch

Abstract readReview
In one paragraph

Review in Klinische Monatsblatter fur Augenheilkunde, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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  8. Review
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  12. Association of the TGF-beta1 polymorphism with primary open-angle glaucoma: a case-control study.Medical hypothesis, discovery & innovation ophthalmology journal · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tienan Qi *Zentrum für Augenheilkunde, Medizinische Fakultät, Universität Köln, Deutschland.
Hanhan Liu *Zentrum für Augenheilkunde, Medizinische Fakultät, Universität Köln, Deutschland.
Layla FrühnZentrum für Augenheilkunde, Medizinische Fakultät, Universität Köln, Deutschland.
Katrin LöwZentrum für Augenheilkunde, Medizinische Fakultät, Universität Köln, Deutschland.
Claus CursiefenZentrum für Augenheilkunde, Medizinische Fakultät, Universität Köln, Deutschland.
Verena ProkoschZentrum für Augenheilkunde, Medizinische Fakultät, Universität Köln, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is one of the leading causes of irreversible blindness worldwide and is often referred to as the "silent thief of sight", because it often progresses without noticeable symptoms until significant vision loss occurs. With an estimated 76 million patients affected in 2020 and a forecast of over 111 million by 2040, the global situation requires urgent attention. Vision loss caused by glaucoma is irreversible but largely preventable, highlighting the importance of early detection and treatment. Diagnosis presents significant challenges, particularly due to the asymptomatic nature of the disease and age-related risk factors. Inequalities in care and access to appropriate treatments are other barriers leading to delayed diagnoses. Early diagnosis and interventions are critical to slow disease progression, protect remaining vision and improve the quality of life of those affected. These measures are particularly important to minimise the psychological impact and impairment in daily activities. The use of innovative technologies and targeted interventions could help improve the early detection and treatment of glaucoma and thus reduce the risk of irreversible vision loss.

Indexed as

BlindnessGlaucomaGlobal HealthEarly DiagnosisHumansRisk Factors

Identifiers

PMID40719087
PMCPMC12302165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.