ArticleFrontiers in oncology2025
Candidate gene mutations of patients with astrocytoma who present with seizures: evidence from whole exome sequencing.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epileptic seizures are common and substantially impact long-term quality of life. However, the risk factors for preoperative seizures among patients with astrocytomas remain unclear. This study aimed to identify the candidate genes associated with seizure before operation among patients with astrocytomas. We conducted a single-center cohort study including 34 patients with astrocytomas that presented with or without preoperative seizures and analyzed differential gene expression, evaluating a total of 142 candidate genes, selected based on a literature review, and categorized into functional groups (e.g., glutamatergic, oncogenic, chromatin-modifying). Clinical characteristics, including age, sex, tumor location, grade, and size, and peritumoral edema, were similar between the seizure and non-seizure groups. Glutamate receptor mutations were identified in 15% of the non-seizure group and 78.6% of the seizure group. Patients with astrocytomas who presented with seizures had significantly more mutations in glutamate-related genes, including
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