ArticleFrontiers in oncology2025
Analysis of cancer-associated glycosyltransferases reveals novel targets of non-small cell lung cancer pathogenesis.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Writers and readers of sialylation in immunoregulation in cancer.The Journal of biological chemistry · 2026Review
- The relevance of sputum galectin-7 levels to clinical and prognostic factors in patients with chronic obstructive pulmonary disease: a prospective cohort study from China.BMC pulmonary medicine · 2026Observational
- Integrative Analysis of Glycosylation-Related Genes Reveals Prognostic Subtypes, Immune Evasion, and Therapeutic Vulnerabilities in Lung Adenocarcinoma.Oncology research · 2026Article
- Adhesion to aggression: unravelling sLeClinical & experimental metastasis · 2025Review
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Authors and funding
10 authors.
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Abstract
Background: Aberrant glycosylation is associated with cancer progression and patient survival, of which the driving genes could act as biomarkers. Our objective was to characterize the expression of glycosylation-related genes to elucidate the heterogeneity between lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), and their prospective diagnostic utility. Methods: mRNA expression data for all glyco-relevant genes was collected from 553 LUSC and 576 LUAD patients from the TCGA dataset. Differential gene expression analysis and UMAP dimension reduction analysis were used to compare mRNA expression in LUAD and LUSC. Selected genes were further confirmed through immunohistochemistry of tissue biopsies. Public single-cell RNA sequencing (scRNA-seq) data from 72 LUSC and 163 LUAD patients was retrieved to study cell type-specific expression. Galectin-7 was measured in patients' plasma by ELISA. Univariate Cox proportional regression model was used for prognostic marker detection. Results: Our analysis revealed genes differentially expressed respectively in LUSC and LUAD compared to normal lung samples. We focused on genes exhibiting high expression in LUSC ( Conclusion: We identified several glyco-associated biomarkers in NSCLC, including Galectin-4, Galectin-7, MUC21, ST6GALNAC1, and ST6GALNAC2. Galectin-7 is a promising clinical biomarker for detection in plasma.
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