ArticleFrontiers in microbiology2025
Gut microbiome and metabolome interactions in Crohn's disease: mechanistic insights into exclusive enteral nutrition-induced remission.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Enteral Nutrition Is Associated with a Distinct Gut Microbiome Composition and Fermentation Capacity Profile After Acute Colonic Injury in Rats.International journal of molecular sciences · 2026Article
- Review
- From dysbiosis to precision medicine: targeting the microbial-metabolic axis in IBD management.Frontiers in cellular and infection microbiology · 2026Review
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Authors and funding
7 authors.
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Abstract
Background: Exclusive enteral nutrition (EEN) is a first-line therapeutic approach for inducing remission in Crohn's disease. However, the underlying mechanisms of its action remain poorly understood. This study aims to investigate the effects of EEN on the gut microbiome and metabolome of CD patients and to elucidate the mechanisms responsible for EEN-induced remission. Methods: Fecal and blood samples were collected from treatment-naïve CD patients ( Results: EEN therapy induced significant structural shifts in the gut microbiome, including a reduction in the abundance of pro-inflammatory bacteria such as Conclusion: This study comprehensively integrates microbiome and metabolome analyses, providing new insights into the mechanism of action of EEN therapy in CD. EEN exerts therapeutic effects by restoring metabolic balance and enhancing the integrity of the intestinal barrier, which may be achieved by reducing pro-inflammatory bacteria and activating antioxidant and energy metabolism pathways.
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