ArticleFrontiers in microbiology2025
HIV drug resistance and its associated factors among patients during interruption of antiretroviral therapy in China.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Non-Canonical Binding of Nelfinavir in HIV-1 Protease Variants Reveals Structural Mechanisms of Antiretroviral Resistance.Viruses · 2026Article
- Trends, Gaps, and Challenges in Antiviral Resistance: A Bibliometric Analysis and Narrative Synthesis of Key Viruses, Resistance Mechanisms, and Drivers.BioMed research international · 2026Article
- Prevalence and determinants of dolutegravir resistance among people living with HIV with virologic failure in North-Eastern Uganda: a retrospective cross-sectional study (2022-2024).Therapeutic advances in infectious diseaseArticle
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11 authors.
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Abstract
Background: The prevalence of human immunodeficiency virus (HIV) drug resistance among people living with HIV (PLWH) who experience treatment interruptions is a significant concern. This study aimed to investigate the prevalence and characteristics of HIV drug resistance for PLWH who experienced treatment interruptions in China. Methods: This study included 595 PLWH from four studies conducted in China between 2003 and 2021. Data were collected through face-to-face questionnaires, and HIV drug resistance was genotyped using an in-house assay. Multivariate logistic regression analysis was performed to identify factors associated with drug resistance. Results: The prevalence of drug resistance was 19.6% (83/424). The most frequent drug resistance mutation was K103N (12.9%). The HIV drug resistance rate and the frequency of patients harboring ≥2 drug resistance mutations decreased significantly in the longer interruption time group. Chi-square trend tests showed that HIV drug resistance, NNRTI drug resistance, K1O3N mutation, and viral load significantly decreased in the longer interruption time group. Multivariate logistic regression analysis revealed that viral load ≥15,000 copies/mL (AOR: 0.58, 95% CI: 0.34-0.98, Conclusion: The study found that the prevalence of HIV drug resistance among PLWH who experienced treatment interruptions in China was 19.6%. These findings highlight the importance of conducting drug resistance tests for patients with interruptions before reinitiating ART, especially when the viral load is> 1,000 copies/mL.
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