Evidence map›Paper›PMID 40718763›Full record

ArticleNPJ dementia2025

Smoking predicts brain atrophy in 10,134 healthy individuals and is potentially influenced by body mass index.

Somayeh Meysami, Saurabh Garg, Sam Hashemi, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Rajpaul Attariwala, Kellyann Niotis, David A Merrill and 1 more

Abstract read
In one paragraph

Article in NPJ dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Somayeh MeysamiPacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA USA.
Saurabh GargPrenuvo, Vancouver, BC Canada.
Sam HashemiPrenuvo, Vancouver, BC Canada.
Nasrin AkbariPrenuvo, Vancouver, BC Canada.
Ahmed GoudaPrenuvo, Vancouver, BC Canada.
Yosef Gavriel ChodakiewitzPrenuvo, Los Angeles, CA USA.
Thanh Duc NguyenPrenuvo, Vancouver, BC Canada.
Rajpaul AttariwalaVoxelwise Imaging Technology, Vancouver, BC Canada.
Kellyann NiotisEarly Medical, Austin, TX USA.
David A MerrillPacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA USA.
Cyrus A RajiWashington University in St Louis Mallinckrodt Institute, St. Louis, MO USA.

Funding

Neuroinflammation and Alzheimer's Disease Imaging Biomarkers in Midlife ObesityR01AG072637 · NIA · WASHINGTON UNIVERSITY · PI RAJI, CYRUS A · 2024 to 2025
$1.4M
NIA NIH HHS R01 AG072637
6 · The paper itself

Abstract

Cigarette smoking is a risk factor for Alzheimer's and vascular dementia, but its impact on brain volume loss, a neurodegeneration biomarker on MRI, is unclear. In total, 10,134 participants from 4 sites were scanned with a whole-body 1.5 T MRI protocol with separate dedicated structural neuroimaging with 3D T1 MPRAGE sequences. Smokers versus non-smokers were compared by gray and white matter volumes normalized to total intracranial volume using a two-tailed

Indexed as

Alzheimer's diseaseDiagnostic markers

Identifiers

PMID40718763
PMCPMC12286857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.