Evidence map›Paper›PMID 40718756›Full record

ArticleNpj flexible electronics2025

Towards Precise Synthetic Neural Codes: High-dimensional Stimulation with Flexible Electrodes.

Robin Kim, Yuxuan Liu, Jiaao Zhang, Chong Xie, Lan Luan

Abstract read
In one paragraph

Article in Npj flexible electronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robin KimDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Yuxuan LiuRice Neuroengineering Initiative, Rice University, Houston, TX 77005, USA.
Jiaao ZhangDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Chong XieDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Lan LuanDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.

Funding

Optimizing ultraflexible electrodes and integrated electronics for high-resolution, large-scale intraspinal recording and modulationU01NS131086 · NINDS · RICE UNIVERSITY · PI Lan Luan, Chong Xie · 2023 to 2026
$5.8M
Maximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordingsU01NS115588 · NINDS · RICE UNIVERSITY · PI FRANK, LOREN M, XIE, CHONG · 2020 to 2023
$4.6M
A Nanoelectronic Strategy for Reliable, Large-scale Chronic Neural RecordingR01NS102917 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI Chong Xie · 2017 to 2026
$3.5M
Longitudinal neuronal and behavioral responses to microstimulation of LGN by ultraflexible electrodesR01EY036094 · NEI · RICE UNIVERSITY · PI Lan Luan, Chong Xie · 2025 to 2026
$1.2M
NEI NIH HHS R01 EY036094NINDS NIH HHS R01 NS102917NINDS NIH HHS U01 NS115588NINDS NIH HHS U01 NS131086
6 · The paper itself

Abstract

Neural representations arise from the spatiotemporally structured activity of neuron populations, inherently residing in high-dimensional spaces. Writing specific information into the central nervous system requires precisely manipulating neural states within this framework. However, current neuromodulation methods lack the precision to fully address this complexity, presenting a significant challenge for advancing effective bidirectional interfaces. In this perspective, we advocate for high-dimensional stimulation as a systematic approach capable of approximating the high dimensionality of natural neural code for brain-machine interface applications. We outline key technological requirements on resolution, coverage, and safety, review recent advances in critical application areas, and highlight the promise of flexible electrode technology in enabling a transformative leap towards precise synthetic neural codes.

Identifiers

PMID40718756
PMCPMC12290909

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.