Evidence map›Paper›PMID 40718646›Full record

ArticleNeuro-oncology advances

Seizure characteristics and outcomes in patients with pleomorphic xanthoastrocytoma.

Daniel J Zhou, Colin A Ellis, Kevin Xie, Nishant Sinha, Sharon X Xie, Kathryn A Davis, Joel M Stein, Tara Jennings, Stephen J Bagley, Arati Desai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel J ZhouCenter for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-0154-8348
Colin A EllisCenter for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-2152-8106
Kevin XieDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1849-2085
Nishant SinhaDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-2090-4889
Sharon X XieDepartment of Biostatistics, Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kathryn A DavisCenter for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joel M SteinDivision of Neuroradiology, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-0741-1780
Tara JenningsPenn Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stephen J BagleyDivision of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-7117-0539
Arati DesaiCenter for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
Patrick Y WenCenter for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
David A ReardonCenter for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
Steven TobochnikCenter for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9071-8398

Funding

Remapping neurology through translation and innovationT32NS091008 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AGUIRRE, GEOFFREY KARL, JENSEN, FRANCES E · 2015 to 2024
$3.0M
Scalable methods to quantify epileptic network and guide epilepsy surgeryK99NS138680 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SINHA, NISHANT · 2024 to 2025
$298k
NINDS NIH HHS K99 NS138680NINDS NIH HHS T32 NS091008
6 · The paper itself

Abstract

Background: Pleomorphic xanthoastrocytomas (PXAs) are rare brain tumors that are often associated with seizures. There are limited data characterizing epilepsy phenotypes in relation to PXA tumor biology and survival outcomes. Methods: This is a retrospective observational study of 35 patients with PXA who received treatment at the University of Pennsylvania or Dana-Farber Cancer Institute. Demographic and clinical features were assessed in PXA patients with or without seizures and with respect to seizure freedom following tumor resection. Results: During their clinical course, 27 (77%) developed tumor-related epilepsy (TRE), with 25 (71%) initially presenting with a seizure. Compared to those without TRE, patients with TRE were more likely to have a Conclusion: These findings indicate that

Indexed as

brain tumoroutcomespleomorphic xanthoastrocytomaseizuretumor-related epilepsy

Identifiers

PMID40718646
PMCPMC12290447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.