ArticleNeuro-oncology advances
Blood-brain barrier disruption following MR-guided laser interstitial thermal therapy.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Outcomes of Laser Interstitial Thermal Therapy-Augmented Surgery in the Management of Subcortical Glioblastoma.Neurosurgery practice · 2026Article
- Laser interstitial thermal therapy in pediatric neurosurgery: a prospective nationwide study on indications, safety, and early outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- MR-Guided Laser Interstitial Thermal Therapy for Recurrent Glioblastoma: A Case Report With Novel Insights Into Histopathological Changes and Immunological Responses.Neuropathology and applied neurobiology · 2026Article
- Laser interstitial thermal therapy for IDH wild-type recurrent glioblastoma: a Scandinavian two-center cohort study.Acta neurochirurgica · 2026Article
- Modulating the glioma microenvironment with laser interstitial thermal therapy: mechanisms and therapeutic implications.Journal of neuro-oncology · 2025Review
- The Role of Blood-Brain Barrier in Brain Cancer: From Pathophysiology to Therapeutic Approaches.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: MR-guided laser interstitial thermal therapy (LITT) is a minimally invasive neurosurgical treatment used for managing brain tumors and drug-resistant epilepsy. This study investigates the temporal pattern of blood-brain barrier (BBB) permeability following LITT in patients with tumors and epilepsy. Methods: Twenty-three patients undergoing LITT (11 with brain tumors, 12 with non-tumor epilepsy) were enrolled. Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) and blood levels of glial fibrillary acidic protein (GFAP) were used to assess BBB permeability one day before and on days 1, 15, 30, and 45 post-LITT. Results: Quantitative analysis using DCE-MRI demonstrated significant increases in perilesional BBB permeability on days 15, 30, and 45 postoperatively ( Conclusions: Quantitative DCE-MRI and GFAP blood levels demonstrate a prolonged window of increased perilesional BBB permeability following LITT, potentially enhancing the delivery and efficacy of therapeutic agents in patients with brain tumors.
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