Evidence map›Paper›PMID 40718635›Full record

ArticleMolecular and clinical oncology2025

Mendelian randomization analysis provides insights into the relationship between inflammatory bowel disease and skin cancer.

Sarem Rashid, Dmitrii Usoltsev, Sameer Gupta, Mykyta Artomov, Hensin Tsao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarem RashidWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114 MA, USA.
Dmitrii UsoltsevBroad Institute, Cambridge, 02142 MA, USA.
Sameer GuptaMassachusetts Eye and Ear, Boston, 02114 MA, USA.
Mykyta ArtomovBroad Institute, Cambridge, 02142 MA, USA.
Hensin TsaoWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114 MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited and conflicting data have been available regarding the association between inflammatory bowel disease and skin cancer. It was hypothesized that inflammatory bowel diseases [Crohn's disease (CD) and ulcerative colitis (UC)] harbor a genetically increased risk of skin cancer [skin cutaneous melanoma (SKCM), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)] and performed two-sample mendelian randomization (MR) analysis using genome-wide association (GWAS) studies of European ancestry retrieved from FinnGen R8. The inverse variance weighted method was used to approximate MR effects. Sensitivity analyses including weighted median, MR-Egger and MR-pleiotropy residual sum and outlier were performed to estimate pleiotropy and heterogeneity

Indexed as

basal cell carcinomaCrohn's diseasecutaneous melanomagenome-wide association studyinflammatory bowel diseasemalignant melanomamendelian randomizationsingle nucleotide polymorphismsquamous cell carcinomaulcerative colitis

Identifiers

PMID40718635
PMCPMC12290388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.