Evidence map›Paper›PMID 40718603›Full record

ArticleEuroasian journal of hepato-gastroenterology

Ewing's Sarcoma of Stomach Masquerading as Gastric Cancer: A Case Report and Literature Review.

Shashi Singh Pawar, Swati Priya, Manish Kumar, Farhan Mohsin, Rajesh Kumar Singh

Abstract read
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Article in Euroasian journal of hepato-gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shashi Singh PawarDepartment of Surgical Oncology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
Swati PriyaDepartment of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
Manish KumarDepartment of Surgical Oncology, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
Farhan MohsinDepartment of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
Rajesh Kumar SinghDepartment of Radiation Oncology, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ewing's sarcomas (ES) are exceedingly malignant undifferentiated small round cell tumors of the neuroectodermal origin. It primarily occurs in the skeletal tissue; however, it has also been documented in extraskeletal tissues, including the small intestine, esophagus, vagina, pancreas, ovaries, rectovaginal septum, prostate, and kidneys.Extraskeletal Ewing sarcoma (EES) constitutes approximately 15-20% of neoplasms within the ES family, which includes both Ewing sarcoma/peripheral neuroectodermal tumors (ES/PNET) and EES. Extraskeletal ES are frequently observed in the paraspinal region, limbs and retro peritoneum. Encountering primary gastric ES is exceptionally rare. Methods and result: We, herby, present here an extremely rare case of primary gastric ES in a 17-year-old male who had presented to us with features of gastric outlet obstruction. Contrast-enhanced abdominal computed tomography revealed an asymmetrical circumferential thickening of about 5 cm in the antropyloric region of the stomach and the first part of the duodenum, with multiple enlarged perigastric lymph nodes. Endoscopic biopsy revealed a tumor composed of cells arranged in nests, cords and sheets. An extensive immunohistochemistry panel examination found tumor cells to be strongly positive for vimentin, NKX2.2, FLI1, CD99 and CK.The patient received 9 weeks of neoadjuvant chemotherapy based on IE-VAC regimen. The patient underwent elective classical pancreaticoduodenectomy (Whipple's procedure). The postoperative course of the patient unfolded without any complications. The patient was subsequently discharged in a state of good health 12 days post-procedure. Thereafter, he underwent four cycles of adjuvant chemotherapy. Discussion: A review of the elucidated cases of primary gastric Ewing's sarcoma depicts its aggressive nature with frequent regional and distant metastasis, and mostly manifesting through non-specific clinical features, thereby, evading early diagnostic efforts. A comprehensive multimodal therapeutic strategy, with chemotherapy, radiotherapy, and surgical intervention is typically employed.We, thus, report this case to help with disease identification and acceptance for the clinicians. How to cite this article: Pawar SS, Priya S, Kumar M,

Indexed as

Abdominal massEwing's sarcomaGastric cancerGastric outlet obstructionGastric tumorsWhipple procedure

Identifiers

PMID40718603
PMCPMC12288588

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