ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Correlation Analysis of Serum TYROBP Level and Metabolic Indexes of Obesity.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the relationship between TYRO protein tyrosine kinase-binding protein (TYROBP), a transmembrane immune signal transduction adaptor, and obesity-related metabolic parameters. Patients and Methods: A total of 54 obese patients, 66 overweight subjects, and 54 normal weight subjects were selected from the Affiliated Hospital of Chengde Medical College from February 2023 to May 2024. Serum TYROBP levels were compared among the three groups, and their correlation with body fat content and other related indicators of body composition analysis was analyzed. The analysis included correlations between serum TYROBP level and human body composition analysis indicators, such as body fat content and obesity-related metabolic indicators: weight-adjusted waist index (WWI), body shape index (ABSI), lipid accumulation index (LAP), cardiometabolic index (CMI), body adiposity index (BAI), and atherogenic index of plasma (AIP). Results: Serum TYROBP levels were significantly elevated in obese patients compared to both normal weight and overweight individuals (p<0.05). Spearman's or Pearson's correlation analyses showed that serum TYROBP levels were positively correlated with age (r=0.232, Conclusion: TYROBP is highly expressed in obese patients, indicating its potential as an independent risk factor for obesity and demonstrating diagnostic value for obesity with metabolic disorders.
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