Evidence map›Paper›PMID 40718565›Full record

ArticleFrontiers in psychology2025

The effects of an immersive virtual reality and telemedicine-based multi-component intervention in individuals with subjective cognitive decline: study protocol of a randomized controlled trial.

Maria Stefania De Simone, Silvia Zabberoni, Alberto Costa, Erika Tenaglia, Gaetano Tieri

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06429215 (Preventing Cognitive Decline and Dementia Through an Innovative Immersive Virtual Reality and Telemedicine-based Multi-component Intervention), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06429215 narecruitingnot on this map

Preventing Cognitive Decline and Dementia Through an Innovative Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: a Randomized Controlled Trial

TypeinterventionalSponsorI.R.C.C.S. Fondazione Santa LuciaRan2024 to 2025Enrolled75ConditionsSubjective Cognitive DeclineArmsMulti-component Intervention (MC-I): VR Cognitive training and Psychoeducation on health and lifestyle, Cognitive-only intervention (CO-I): VR Cognitive training (+ Psychoeducation active control), Active control intervention (AC-I): VR Cognitive active control + Psychoeducation active control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Stefania De SimoneDepartment of Economics, Psychology, Communication, Education, and Motor Sciences, Niccolò Cusano University, Rome, Italy.
Silvia ZabberoniDepartment of Economics, Psychology, Communication, Education, and Motor Sciences, Niccolò Cusano University, Rome, Italy.
Alberto CostaDepartment of Economics, Psychology, Communication, Education, and Motor Sciences, Niccolò Cusano University, Rome, Italy.
Erika TenagliaDepartment of Economics, Psychology, Communication, Education, and Motor Sciences, Niccolò Cusano University, Rome, Italy.
Gaetano TieriVirtual Reality and Digital Neuroscience Lab, Department of Law and Digital Society, University of Rome Unitelma Sapienza, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Older adults with subjective cognitive decline (SCD) are at high risk of developing dementia and frequently experience subclinical symptoms (e.g., anxiety, depression) which are themselves associated with an increased dementia and cognitive decline risk. Our aim is to test the effects of an immersive virtual reality (IVR) and telemedicine-based multi-component intervention, that combines cognitive training and health and lifestyle education program, in individuals with SCD. Methods: To assess the efficacy of the intervention, a randomized, double-blinded controlled trial will be conducted on a sample of 75 individuals with SCD. Participants will be randomly assigned to one of three conditions: (a) multi-component intervention, including SCD-tailored cognitive IVR training plus a health and lifestyle education program, (b) cognitive-only intervention, including SCD-tailored cognitive IVR training Discussion: Our results will provide new evidence of the efficacy of an innovative multi-component intervention integrating IVR and telemedicine in SCD individuals. Considering the relatively low costs and easy accessibility, it could be a valuable contribution to primary prevention initiatives for dementia risk reduction. Trial registration: This trial was prospectively registered at ClinicalTrials.gov on May 24, 2024 (registration number: NCT06429215).

Indexed as

cognitive trainingeducation programimmersive virtual realitymemorysubjective cognitive declinetelemedicine

Identifiers

PMID40718565
PMCPMC12289650

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.