ArticleACS photonics2025
Multiplexed Chromatin Analysis Using Optical Spectroscopic Statistical Nanosensing.
Article in ACS photonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Temporal variance mapping with machine learning for label-free 3D chromatin imaging using optical interferometric microscopy.Biomedical optics express · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In single cells, chromatin packs into organized structures to perform biological functions, such as RNA transcription regulation. Characterizing such structural behaviors, including packing density and mass scaling, is critical in epigenetics research. Partial wave spectroscopic (PWS) microscopy is a label-free, live-cell, high-throughput imaging modality that utilizes optical spectroscopic statistical nanosensing. Rather than resolving the exact chromatin packing structure, PWS extracts statistical packing information from spectroscopic interference signals. In this study, we evaluate its ability to characterize multiplexed chromatin packing density and mass scaling, as well as its spatial confidence interval, using finite difference time domain (FDTD) electromagnetic simulations. We validated the simulation-based analysis algorithm by comparing experimental PWS images against coregistered super-resolution acquisitions, confirming its accuracy in capturing chromatin packing metrics. We then applied this modality to live cells treated with different epigenetic agents, mapping spatial changes in chromatin packing in a high-throughput workflow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.