ArticleFrontiers in immunology2025
Association between neutrophil percentage-to-albumin ratio and rheumatoid arthritis: a cross-sectional study from US population, 1999-2018.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association of Neutrophil Percentage-to-Albumin Ratio With Urinary Albumin Excretion in U.S. Adults: Implications for Rheumatic Disease Research.International journal of rheumatic diseases · 2026Article
- Association between lipid accumulation product and visceral adiposity index and rheumatoid arthritis: NHANES 1999-2018.Lipids in health and disease · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Rheumatoid arthritis (RA) is linked to systemic inflammation and immune dysregulation. The neutrophil-percentage-to-albumin ratio (NPAR), integrating neutrophil activity and nutritional status, may reflect inflammatory and immune responses. However, its association with RA remains unexplored. We aimed to investigate the relationship between NPAR and RA using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Methods: This cross-sectional study utilized data from NHANES including 38,272 participants. The NPAR was calculated based on the neutrophil percentage (in total WBC count) (%), and albumin value (g/dL). We employed weighted multivariable logistic regression analysis and subgroup analysis to examine the association between NPAR and RA, adjusting for sociodemographic, lifestyle, and clinical covariates. Restricted cubic splines were used to assess potential non-linear relationships. Additionally, receiver operating characteristic (ROC) was performed to determine the predictive accuracy of NPAR compared with other inflammatory markers. Results: After adjusting for all covariates, multivariable logistic regression indicated that elevated levels of NPAR were significantly associated with an increased risk of RA (OR Conclusion: Overall, our study demonstrates a significant positive association between NPAR and RA prevalence in U.S. adults, particularly when NPAR levels exceeded 13.6. Our findings underscore the critical role of immune-nutritional interactions in RA pathogenesis. However, owing to the cross-sectional design, prospective longitudinal investigations are warranted to establish causality and elucidate underlying biological mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.