ArticleFrontiers in immunology2025
Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bovine blood cells during systemic immune challenge.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
L-carnitine plays a key role in shuttling free fatty acids from the cytosol into the mitochondrial matrix. Fatty acids, among other substrates, are utilized by immune cells as an energy source. Therefore, L-carnitine, which is authorized as a feed additive in cattle, may influence the metabolism of peripheral blood mononuclear cells (PBMC) during an immune challenge. To test this hypothesis, a feeding trial was conducted with 53 German Holstein cows, comprising a control group (CON, n = 26) and an L-carnitine supplemented group (CAR, n = 27, 25 g rumen-protected L-carnitine/cow/d). On day 111 after calving, all cows were intravenously injected with lipopolysaccharides (LPS, 0.5 µg/kg body weight as bolus injection,
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