ArticleIranian journal of pharmaceutical research : IJPR
Investigation of the Antioxidant and Cellular Toxicity Activities of Gold Nanoparticles Synthesized Using
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Green synthesis, characterization, evaluation of anticancer and antioxidant potentials of gold and copper oxide nanoparticles using jujube fruit extract.Scientific reports · 2026Article
- Anticancer activity of nanoemulsion formulation of Chicorium intybus L. seed extract on human breast cancer cells.Scientific reports · 2025Article
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Authors and funding
3 authors.
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Abstract
Background: Liver cancer is increasing in different parts of the world and is the fourth leading cause of cancer death globally. Objectives: The present study aims to synthesize and analyze the characterization of gold nanoparticles (AuNPs) synthesized by Methods: The synthesized AuNPs were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and fourier-transform infrared spectroscopy (FTIR). The antioxidant activity of the nanoparticles was assessed using the DPPH test, and their cytotoxicity activity was analyzed using the MTT method. Results: The results indicate that the AuNPs are crystalline materials with a particle size of less than 100 nm, with a mean particle size of 23.94 nm. The FTIR study reveals the presence of biochemical groups that act as reducing factors. The results demonstrate that antioxidant activity increases with concentration, with 87% inhibition of DPPH free radical scavenging observed at 250 µg/mL. Cell toxicity results in liver cancer cell lines (HepG2) demonstrated significant cytotoxicity in a time- and dose-dependent manner. The percentage of cell viability at a concentration of 1000 µg/ml after 24, 48, and 72 hours was determined to be 45%, 51%, and 22%, respectively. Conclusions: The present study revealed the simple cost-effective and environmentally friendly method that could be employed from food to pharmaceutical industries.
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