SynthesisFrontiers in cardiovascular medicine2025
Comparative effectiveness of statins and exercise in high-risk individuals: systematic review and network meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background and aims: Arterial stiffness (AS) predicts cardiovascular disease (CVD) risk and relates to multiple factors. But the best interventions for AS in high-risk CVD groups are unknown. This review focuses on how different interventions affect AS and related indicators. Methods: We searched MEDLINE (PubMed), Embase, Cochrane Library, EBSCO, and Web of Science for relevant studies. Inclusion criteria: (1) randomized controlled trials (RCT); (2) participants with CVD risk factors as per American College of Sports Medicine (ACSM) guidelines; (3) interventions including Whole-Body Vibration (WBV), statins (STA), interval training (INT), aerobic exercise (AE), resistance exercise (RT), and combined exercise (CT); (4) control groups with usual care or placebo; (5) outcomes of pulse wave velocity (PWV), systolic blood pressure (SBP), and diastolic blood pressure (DBP); (6) studies in English. Data were analyzed using a random effects network meta-analysis and assessed for bias using the Cochrane tool. Results: This meta-analysis of 58 studies ( Conclusions: For CVD high-risk populations, high doses of statins (hSTA) optimally reduces AS; WBV is the top non-drug AS intervention, while INT best improves both AS and BP short-term. Combined, these interventions significantly enhance outcomes. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=564538, PROSPERO CRD42024564538.
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