ArticleHuman reproduction open2025
Effects of different embryo culture media on birthweight following assisted reproductive technology.
Article in Human reproduction open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Reduced oxygen tension during embryo culture and neonatal growth outcomes: a large retrospective cohort study of 13,831 fresh IVF/ICSI singleton births.Journal of assisted reproduction and genetics · 2026Article
- Reproductive fluids, commercial media, and organoids: bridging the gap in IVF culture systems.Human reproduction open · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
study questionDoes the type of embryo culture medium affect the birthweight of newborns conceived by ART? SUMMARY ANSWER: After fresh embryo transfers, singleton newborns in the G5 and HTF groups exhibited higher birthweight WHAT IS KNOWN ALREADY: Current studies have not yet determined whether embryo culture medium affects birthweight and, if such an effect does exist, the significance of embryo culture medium among all the influencing factors is not yet clear. STUDY DESIGN SIZE DURATION: A retrospective cohort study including 23 403 fresh ET cycles between 1 January 2010 and 31 December 2022 at the reproductive medical center of a university-affiliated hospital was conducted. PARTICIPANTS/MATERIALS SETTING
methodsWe performed a retrospective cohort study including 23 403 fresh ET cycles. Four embryo culture media were analyzed: Cook, G5-PLUS, G5, and HTF. Multiple linear regression analysis was used to evaluate potential associations between embryo culture medium and birthweight MAIN RESULTS AND THE ROLE OF CHANCE: The cohort comprised 4453, 8460, 7463, and 3027 singletons in the Cook, G5-PLUS, G5, and HTF groups, respectively. Compared to the Cook group, newborns in the G5 and HTF groups had higher birthweight LIMITATIONS REASONS FOR CAUTION: Due to commercial and regulatory reasons, various culture media were used for different periods, thus resulting in the different number of cases for the four culture media groups. WIDER IMPLICATIONS OF THE
findingsOur analysis revealed that the type of embryo culture medium directly affected birthweight STUDY FUNDING/COMPETING INTERESTS: This study was supported by National Key Research and Development Program of China (2023YFC2705604 and 2024YFC2706900) and the National Natural Science Foundation of China (82071721, 82371706, and 82288102). All authors have no conflicts of interest to report. TRIAL REGISTRATION NUMBER: N/A.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.