ArticleCureus2025
Rapid Eye Movement (REM)-Predominant Central Sleep Apnea With Alpha-Delta Sleep Pattern: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central sleep apnea (CSA) occurring predominantly during rapid eye movement (REM) sleep represents an unusual clinical phenomenon, as CSA typically occurs during non-rapid eye movement (NREM) sleep. We present the case of a 32-year-old male with severe obstructive sleep apnea (OSA), with an apnea-hypopnea index (AHI) of 65.5/hr, who exhibited central apneas mainly during REM sleep (central apnea index: 35.9/hr in REM vs. 5.2/hr in NREM), along with concurrent alpha-delta sleep pattern during slow-wave sleep. The patient was taking tramadol 100 mg and pregabalin 300 mg daily for chronic back pain. Continuous positive airway pressure (CPAP) therapy at 6 cmH₂O effectively managed the OSA and resolved both central apneas and the alpha-delta sleep pattern despite continued medication use. The CPAP therapy reduced the total AHI from 65.5/hr to 1.3/hr, with the central apnea index decreasing from 35.9/hr to 0/hr during REM sleep. This case contributes to the limited literature on REM-predominant CSA and demonstrates the efficacy of standard CPAP therapy in this uncommon presentation, suggesting complex interactions among pharmacological agents, sleep architecture, and respiratory control mechanisms.
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