ArticleTobacco induced diseases2025
Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES.
Article in Tobacco induced diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionα-Klotho is a circulating protein linked to longevity and healthy aging. While tobacco use is known to reduce α-Klotho levels, the effects of marijuana use on this aging-related biomarker remain unclear. This study aimed to examine the association between marijuana use and serum α-Klotho levels in a nationally representative sample of US adults.
methodsWe conducted a secondary analysis of publicly available data from the National Health and Nutrition Examination Survey (NHANES) 2007-2016, including 6601 adults aged 40-59 years with available serum α-Klotho levels and complete substance use data. Multivariable linear regression models were used to estimate the association between marijuana use and α-Klotho levels.
resultsCurrent marijuana use was significantly associated with lower serum α-Klotho levels compared to never use (β= -0.084; 95% CI: -0.126 - -0.041), independent of tobacco and illicit drug use. In the combined exposure model, those using both marijuana and tobacco exhibited the greatest reduction in α-Klotho (β= -0.112; 95% CI: -0.162 - -0.062). The inverse association persisted across most subgroups, including both current smokers (β= -0.078; 95% CI: -0.134 - -0.021) and non-smokers (β= -0.087; 95% CI: -0.151 - -0.002).
conclusionsMarijuana use was independently associated with lower circulating α-Klotho levels, suggesting a potential link between cannabis exposure and accelerated biological aging, even after adjusting for tobacco use. These findings highlight the need for further longitudinal studies to investigate the long-term impact of marijuana and tobacco use on systemic aging processes and health effects.
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