ArticleJournal of inflammation research2025
Rbms3 Upregulation in Mesenchymal Stem Cells Impairs Fracture Healing in Type 2 Diabetes Mellitus.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Fracture healing can be delayed or impaired in individuals with abnormal conditions, including Type 2 Diabetes Mellitus (T2DM). Mesenchymal stem cells (MSCs) are critical to the process of fracture healing and are found to be impaired in T2DM. Although some research has been conducted to address this, the specific mechanisms remain poorly understood and warrant further exploration. Methods: We downloaded transcriptomic and single-cell RNA sequencing (scRNA-seq) data, performed multiple analyses (differential expression, ssGSEA, co-expression, GO, KEGG, GSEA, and cell clustering identification), and utilized tools (GeneMINIA and Metascape) to investigate alterations in MSCs under diabetic condition. Further validation and exploration were carried out through in vitro experiments (cell transduction, flow cytometry, ALP staining, ARS, qPCR, and Western blotting) and in vivo experiments (micro-CT, histological staining, and immunohistochemistry). Results: Our study identified differentially expressed genes from fracture healing and non-union cases in human samples, suggesting abnormal immune infiltration and disrupted biological processes. ScRNA-seq analysis further revealed significant alterations in MSCs under diabetic conditions with enriched pathways, including MAPK, TGF-β, and P53 signaling pathways. Integrating with transcriptomic analysis, we identified Conclusion: The upregulation of
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