ArticleJournal of inflammation research2025
Potential Metabolic Markers in the Tongue Coating of Chronic Gastritis Patients for Distinguishing Between Cold Dampness Pattern and Damp Heat Pattern in Traditional Chinese Medicine Diagnosis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A scale for assessing the health of children aged 3-6 years in China: development and validation of the TCM constitution scale (3-6 years).Frontiers in public health · 2025Article
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7 authors.
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Abstract
Background: Dampness pattern, a prevalent traditional Chinese medicine (TCM) pattern in chronic gastritis (CG), includes cold dampness (CD) and damp heat (DH) patterns. Tongue coating differences are key diagnostic markers, yet molecular-level analyses are lacking. We applied metabolomics to identify differential metabolites distinguishing these patterns. Methods: In this study, the first principal component was analyzed by the OPLS-DA model. The model quality was evaluated by 7-fold cross-validation, and the model validity was evaluated based on Results: Twenty significant differential metabolites emerged ( Conclusion: Metabolite profiles significantly differed between CD and DH. Glycerophospholipid metabolism was central, with phosphatidylethanolamine as a key metabolite. Phenol requires further validation as a diagnostic biomarker. These findings advance quantitative diagnosis and mechanistic insights into TCM dampness syndrome in CG.
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