ArticleAsia Pacific allergy2025
Predictive significance of 15(S)-hydroxyeicosatetraenoic acid for eosinophilic chronic rhinosinusitis with nasal polyps.
Article in Asia Pacific allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Among the different endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP), eosinophilic CRSwNP (ECRSwNP) exhibits more severe symptoms and a higher rate of recurrence compared with noneosinophilic CRSwNP (non-ECRSwNP), as well as distinct metabolic alterations. Hence, early identification of metabolic alterations in polyps is crucial for the prediction and selection of personalized treatment for patients with CRSwNP, especially ECRSwNP. However, clinical practice faces a deficiency in readily accessible and expedited predictive diagnostics of metabolic changes. Objective: This study aimed to assess the capacity of 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) concentrations in nasal secretions to classify endotypes and predict the recurrence of CRSwNP. Methods: Levels of 15(S)-HETE in nasal secretions were measured via enzyme-linked immunosorbent assay (ELISA) in 57 patients with ECRSwNP and 49 patients with non-ECRSwNP. The expression and distribution of ALOX15 were assessed by immunohistochemical staining. In addition, multivariate logistic regression analysis was conducted to identify predictive factors for polyp recurrence. The optimal cutoff value was determined as the point on the receiver operating characteristic (ROC) curve with the maximum Youden Index. Results: The concentration of 15(S)-HETE in nasal secretions was significantly higher in the ECRSwNP group (median [interquartile range (IQR)]: 294.34 ng/mL [83.23-701.34 ng/mL]) than in the non-ECRSwNP group (median [IQR]: 100.19 ng/mL [25.53-207.25 ng/mL]) ( Conclusion: 15(S)-HETE in nasal secretions, as measured by ELISA, can serve as a reliable and alternative indicator for identifying ECRSwNP and predicting CRSwNP recurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.