ArticleFrontiers in nutrition2025
Associations between vitamin K and systemic immune and inflammation biomarkers: a population-based study from the NHANES (2007-2020).
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Role of Fat-Soluble Vitamins in the Prevention and Management of Atopic Dermatitis.International journal of molecular sciences · 2026Review
- Dietary Vitamin K Intake and Insulin Resistance Markers in U.S. Adults: NHANES 2001-2018.Journal of clinical medicine · 2026Article
- Vitamin K as an Endocrine Modulator: Mechanistic Links to Glucose Metabolism and Beyond.Nutrients · 2026Review
- A Case of Childhood Lupus Anticoagulant-Hypoprothrombinemia Syndrome with Diagnostic and Therapeutic Insight.Pediatric health, medicine and therapeutics · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: With the aging of the population, finding effective interventions and treatments to delay chronic inflammation-related diseases is an urgent problem to be solved. Previous studies on animals have proposed that vitamin K can inhibit inflammation and may be a potential regulator of the immune inflammatory response. These findings suggested that increasing intake of vitamin K might also help reduce inflammation. Methods: This study included 36,895 people from the National Health and Nutrition Examination Survey (2007-2020). Multivariate linear regression and restricted cubic spline analyses were conducted to explore the association between vitamin K intake and various immune inflammatory factors. Subgroup analyses were performed based on age, gender, ethnicity, BMI, hyperlipidemia, diabetes and hypertension. Results: After multivariable adjustment, vitamin K intake is negatively correlated with SII, SIRI, SIIRI, NLR, white blood cell, neutrophil, and monocyte. When the level of vitamin K intake was less than 237.7 mcg/d, RAR showed a significant decreasing trend with the increase of vitamin K. When the vitamin K intake level was lower than 75.1 mcg/d, the basophil showed a downward trend with the increase of intake. However, when vitamin K levels exceed the inflection point, the above association no longer exists. Conclusion: These findings reveal that vitamin K intake is associated with reduced inflammatory status and improvements in immune inflammatory biomarkers. Vitamin K may modulate systemic immune and inflammatory markers, which may play a role in the development of chronic inflammation.
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