SynthesisFrontiers in pharmacology2025
Long-term efficacy of CDK4/6 inhibitors in early HR+, HER2- high-risk breast cancer: An updated systematic review and meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Oncofertility in the Age of HER2 Blockade, Immunotherapy, PARP inhibitors, CDK4/6 inhibitors and Endocrine Treatment: Unanswered Questions in Breast Cancer.Current treatment options in oncology · 2026Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The confirmed efficacy of combining CDK4/6 inhibitors with endocrine therapy (ET) in HR+, HER2- early breast cancer patients in longer follow-up necessitates further investigation. This meta-analysis aims to comprehensively assess the impact of follow-up duration on the therapeutic activity in high-risk patients. Methods: We systematically searched PubMed, Cochrane Library, Embase, Medline, Web of Science, and relevant conference abstracts up to 19 October 2024. The included RCTs examined CDK4/6 inhibitors with ET in HR + HER2- early breast cancer patients. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated to analyze invasive disease-free survival (iDFS). Results: Four RCTs with 3-year and 4-year iDFS data (n = 17,749) were included. The results showed that the CDK4/6 inhibitor group had significantly better iDFS compared to the ET group at both 3 years (HR = 0.81, 95% CI 0.70-0.94, P = 0.006) and 4 years (HR = 0.78, 95% CI 0.66-0.94, P = 0.007). Subgroup analysis revealed that in LN + patients, the CDK4/6 inhibitor group also had significantly better iDFS at both 3 years (HR = 0.84, 95% CI 0.73-0.97, P = 0.02) and 4 years (HR = 0.74, 95% CI 0.68-0.81, P < 0.00001). For N0 patients, iDFS benefits became more evident over time. At 4 years, combination therapy showed significant improvement (HR = 0.65, 95% CI 0.45-0.94, P = 0.02). For stage II patients, CDK4/6 inhibitors combined with ET showed no statistically significant difference in iDFS at treatment completion (HR = 0.78, 95% CI 0.59-1.05, P = 0.10), but significantly improved iDFS at 4 years (HR = 0.66, 95% CI 0.50-0.87, P = 0.003). Conclusion: The iDFS improvement with CDK4/6 inhibitors becomes more evident over time, suggesting broader benefits and enhanced long-term efficacy for HR+, HER2-breast cancer patients especially with N0 or Stage II. Systematic Review Registration: PROSPERO database, CRD42024593864.
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