ArticleFrontiers in public health2025
Pre-COVID health-related quality of life predicts symptoms and outcomes for patients with long COVID.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects of the COVID-19 pandemic on working conditions and mental health among employees in health and social services.Frontiers in public health · 2026Article
- Impact of COVID-19 on Health-Related Quality of Life and Mental Health Among Employees in Health and Social Services-A Longitudinal Study.Infectious disease reports · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Post-acute sequelae SARS-CoV-2 (PASC) is a prevalent condition with variable symptom presentation. PASC occurs more often with pre-existing medical conditions, however it is unknown whether pre-COVID health-related quality of life (HRQL) is associated with PASC. Similarly, the trajectory of HRQL following PASC is unknown. Objective: Our study sought to evaluate (1) whether pre-COVID HRQL is associated with PASC symptoms; (2) whether PASC patients have worse pre-COVID HRQL compared to matched controls; and (3) to compare HRQL trajectories from pre-COVID to 1-year follow-up between PASC patients and matched controls. Design: Retrospective cohort study with propensity-score matched control group. Participants: The cohort included 1,114 adult patients (mean age 53 ± 14, 75% female) seen in a PASC clinic between 2/10/21 and 3/27/24 who completed HRQL surveys prior to their initial COVID-diagnosis in a large health system. A propensity-score matched control group included patients with COVID-19 without PASC. Main measures: HRQL was measured with PROMIS Global Health [global mental health (GMH) and global physical health (GPH) summary scores]. Key results: PASC symptoms were significantly associated with pre-COVID HRQL. Symptoms most associated with PROMIS-GMH included diarrhea/nausea [odds ratio (OR) = 1.27 (95% CI: 1.16-1.39) per five-point worsening] and brain fog [OR = 1.25 (95% CI: 1.14-1.37)], while fatigue [OR = 1.39 (95% CI: 1.15-1.68)] had the highest association with PROMIS-GPH. Pre-COVID GMH and GPH were significantly worse for PASC patients compared to controls [-2.6 (SE 0.4) and -3.4 (0.3) Conclusions: In patients with PASC, worse pre-COVID HRQL was associated with more PASC-related symptoms. PASC patients had worse pre-COVID HRQL compared to matched controls and experienced a greater decline in HRQL 1-year after COVID-diagnosis; however, this decline was below the threshold for clinical significance.
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